Abstract
To search for novel therapeutic compounds with higher activity, a series of novel dehydroabietic acid derivatives bearing 1,3,4-oxadiazole moieties were designed and synthesized. Ten title compounds 5-dehydroabietyl-2-alkyl thio-1,3,4-oxadiazoles were synthesized by the reaction of 5-dehydroabietyl-2-mercapto-1,3,4-oxadiazole with alkyl halide or substituted benzyl halide in ethanolic KOH. All the title compounds were analyzed and characterized by means of IR, UV-vis, EI-MS, 1H-NMR, 13C-NMR, and elemental analysis. The preliminary herbicidal assay showed that almost all of the compounds exhibited an excellent growth inhibition to rape (Brassica campestris) and a certain inhibition to barnyard grass (Echinochloa crusgalli L.) at a concentration of 100 μg ml-1.
Relationship between Chemical Structure and Selectivity in Herbicidal Activity oftrans-β-(2,4-Dichlorophenoxy)-acrylates against Rice Plant and Barnyard-grass